Endocrine Abstracts

A 62-year-old lady was assessed following discovery of a retroperitoneal tumour on a CT scan. Fifteen years previously she was diagnosed with irritable bowel syndrome with alternating constipation and diarrhoea, however, within the last 5 years, diarrhoea was the dominant feature with bowel opening every 20 min daily. Investigations for inflammatory bowel disease, hyperthyroidism and coeliac disease were negative. Her anal sphincter was found to be non-functioning and a colost...

Background: Thyroid ultrasound (US) is not routinely used in the evaluation of hyperthyroidism, although studies show that clinical exam may miss lesions up to 2 cm in diameter. We reviewed our department’s practice of thyroid US to consider (1) accuracy of our clinical diagnosis and (2) whether this could improve management. Our hospital has no facility for isotope scanning.Methods: Seventy-three cases (13 male, 60 female) identified from thyroid U...

Audit was performed to identify outcomes of patients from our department referred for RAI for thyrotoxicosis over 14 month period. Follow-up data of atleast 6 months was required for inclusion. Forty-eight patients were identified; four were excluded due to insufficient follow-up. Diagnoses were: Graves’ disease (n=35; 79.5%), multinodular disease (MND) (n=8; 18.2%) and Amiodarone induced thyrotoxicosis (AIT) (n=1; 0.02%)....

A 35-year-old woman was referred with biochemical hyperthyroidism (T4 30 pmol/l; T3 7 pmol/l) without TSH suppression (5.4 mIU/l). She was 7 weeks pregnant following natural conception, and reported no symptoms of hyperthyroidism. Migraines had been a feature in very early pregnancy, but her medical history was otherwise unremarkable and there was no significant family history. Examination findings were entirely normal.Investigation...

Background and aims: Thiazolidinediones have been extensively used as second line agents in the management of type 2 diabetes. A small increased incidence of ischaemic heart disease was suggested by a meta-analysis of studies using Rosiglitazone. Similar meta-analysis of Pioglitazone did not show adverse cardiovascular outcomes. Our aim was to objectively evaluate the changes in glycaemic and lipid control in a controlled conversion from Rosiglitazone to Pioglitazone.<p cl...